Monday, September 5, 2011

TB vaccine candidate shows early promise

ScienceDaily (Sep. 4, 2011) ? Researchers at Albert Einstein College of Medicine of Yeshiva University report in the September 4 online edition of Nature Medicine that they have developed a tuberculosis (TB) vaccine candidate that proved both potent and safe in animal studies.? According to the World Health Organization, TB kills an estimated 1.7 million people each year and infects one out of three people around the globe. With drug-resistant strains spreading, a vaccine for preventing TB is urgently needed.

"Producing effective TB vaccines requires a better understanding of the mechanisms used by Mycobacterium tuberculosis [the bacterial species that causes TB] to evade the body's immune responses," said senior author William Jacobs, Jr., Ph.D., professor of microbiology & immunology and of genetics at Einstein and a Howard Hughes Medical Institute investigator. He notes that the only currently used vaccine, the Bacille Calmette-Gu?rin (BCG) vaccine, has been notoriously inconsistent in protecting against TB.

To determine how M. tuberculosis outwits the immune response, Dr. Jacobs and his colleagues worked with a closely related species known as Mycobacterium smegmatis that is lethal to mice at high doses but does not harm people. The researchers created a version of M. smegmatis lacking a set of genes, known as ESX-3, considered crucial for evading host immunity. When high doses of the altered bacteria were infused into mice, it became clear that bacteria lacking the ESX-3genes could no longer evade their hosts' immune system: the mice controlled and cleared the infection through a robust T-cell response -- the same response a successful TB vaccine would elicit.

Unfortunately, Dr. Jacobs found that removing the same set of genes from M. tuberculosis killed the bacterium?which meant M. tuberculosis could not be manipulated in this way to make a vaccine. But Dr. Jacobs and his colleagues found a way around this stumbling block. They took the M. smegmatis bacteria lacking ESX-3 and inserted the analogous set of M. tuberculosis ESX-3 genes. These M. smegmatis bacteria were then infused into mice, which once again fought off the infection. And eight weeks later, when the mice were challenged with high doses of M. tuberculosis -- which kills mice as well as people -- these "vaccinated" mice lived much longer than control mice: an average survival time of 135 days vs. 54 days.

Just as impressive, said Dr. Jacobs, was the markedly reduced level of TB bacteria found in the animals' tissues. "Most notably," he said, "those vaccinated animals that survived for more than 200 days had livers that were completely clear of TB bacteria, and nobody has ever seen that before."

Dr. Jacobs cautioned that only about one in five mice showed this robust response -- indicating that the vaccine must be improved before it can be considered sufficiently effective. "We don't even know yet if it will work in humans, but it's certainly a significant step in efforts to create a better TB vaccine," he said.

Aeras, a Rockville, MD-based non-profit development partnership dedicated to preventing TB, has licensed the technology described in this study and is using it to develop a new TB vaccine. The technology could also provide the basis for vaccines that eliminate leprosy and other virulent mycobacteria from infected tissues.

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The above story is reprinted (with editorial adaptations by ScienceDaily staff) from materials provided by Albert Einstein College of Medicine.

Journal Reference:

  1. Kari A Sweeney, Dee N Dao, Michael F Goldberg, Tsungda Hsu, Manjunatha M Venkataswamy, Marcela Henao-Tamayo, Diane Ordway, Rani S Sellers, Paras Jain, Bing Chen, Mei Chen, John Kim, Regy Lukose, John Chan, Ian M Orme, Steven A Porcelli, William R Jacobs. A recombinant Mycobacterium smegmatis induces potent bactericidal immunity against Mycobacterium tuberculosis. Nature Medicine, 2011; DOI: 10.1038/nm.2420

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/dj70ZKnZPzg/110904140447.htm

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Sunday, September 4, 2011

Documents show ties between Libyan spy head, CIA (AP)

TRIPOLI, Libya ? The CIA and other Western intelligence agencies worked closely with the ousted regime of Moammar Gadhafi, sharing tips and cooperating in handing over terror suspects for interrogation to a regime known to use torture, according to a trove of security documents discovered after the fall of Tripoli.

The revelations provide new details on the West's efforts to turn Libya's mercurial leader from foe to ally and provide an embarrassing example of the U.S. administration's collaboration with authoritarian regimes in the war on terror.

The documents, among tens of thousands found in an External Security building in Tripoli, show an increasingly warm relationship, with CIA agents proposing to set up a permanent Tripoli office, addressing their Libyan counterparts by their first names and giving them advice. In one memo, a British agent even sends Christmas greetings.

The agencies were known to cooperate as the longtime Libyan ruler worked to overcome his pariah status by stopping his quest for weapons of mass destruction and renouncing support for terrorism. But the new details show a more extensive relationship than was previously known, with Western agencies offering lists of questions for specific detainees and apparently the text for a Gadhafi speech.

They also offer a glimpse into the inner workings of the now-defunct CIA program of extraordinary rendition, through which terror suspects were secretly detained, sent to third countries and sometimes underwent the so-called enhanced interrogation tactics like waterboarding.

The documents mention a half dozen names of people targeted for rendition, including Tripoli's new rebel military commander, Abdel-Hakim Belhaj.

Peter Bouckaert of Human Rights Watch, which helped find the documents, called the ties between Washington and Gadhafi's regime "A very dark chapter in American intelligence history."

"It remains a stain on the record of the American intelligence services that they cooperated with these very abusive intelligence services," he said Saturday.

The findings could cloud relations between the West and Libya's new leaders, although Belhaj said he holds no grudge. NATO airstrikes have helped the rebels advance throughout the six-month civil war and continue to target regime forces as rebels hunt for Gadhafi.

Belhaj is the former leader of the Libyan Islamic Fighting Group, a now-dissolved militant organization that sought to assassinate Gadhafi.

Belhaj says CIA agents tortured him in a secret prison in Thailand before he was returned to Libya and locked in the notorious Abu Salim prison. He insists he was never a terrorist and believes his arrest was in reaction to what he called the "tragic events of 9/11."

Two documents from March 2004 show American and Libyan officials arranging Belhaj's rendition.

Referring to him by his nom de guerre, Abdullah al-Sadiq, the documents said he and his pregnant wife were due to travel to Thailand, where they would be detained.

"We are planning to arrange to take control of the pair in Bangkok and place them on our aircraft for a flight to your country," they tell the Libyans. The memo also requested that Libya, a country known for decades for torture and ill-treatment of prisoners: "Please be advised that we must be assured that al-Sadiq will be treated humanely and that his human rights will be respected."

The documents coincide with efforts by the Gadhafi regime over the last decade to emerge from international isolation, even agreeing to pay compensation to relatives of each of the 270 victims of the 1988 bombing of a Pan Am jumbo jet over Lockerbie, Scotland.

The documents show the CIA and MI6 advising the regime on how to work to rescind its designation as a state sponsor of terror ? a move the Bush administration made in 2006. Both agencies received intelligence benefits in return.

The validity of the documents, not written on official letterhead, could not be independently verified, but their content seems consistent with what has been previously reported about intelligence activities during the period.

Later correspondence deals with technical visits to Libya to track the regime's progress in dismantling its weapons programs.

In one undated memo, the CIA proposes establishing a permanent presence in Libya.

"I propose that our services take an additional step in cooperation with the establishment of a permanent CIA presence in Libya," it says. It is signed by hand "Steve."

Another memo is a follow-up query to an apparent Libyan warning of terror plots against American interests abroad.

One document is a draft statement for Gadhafi about his country's decision to give up weapons of mass destruction.

"Our belief is that an arms race does not serve the security of Libya or the security of the region and contradicts Libya's great keenness for world peace and security," it suggests as wording.

But much of the correspondence deals with arrangements to render terror suspects to Libya from South Africa, Hong Kong and elsewhere. One CIA memo from April 2004 tells Libyan authorities that the agency can deliver a suspect known as "Shaykh Musa."

"We respectfully request an expression of interest from your service regarding taking custody of Musa," the memo says.

CIA spokeswoman Jennifer Youngblood declined to comment Saturday on specific allegations related to the documents.

"It can't come as a surprise that the Central Intelligence Agency works with foreign governments to help protect our country from terrorism and other deadly threats," Youngblood said. "That is exactly what we are expected to do."

British Foreign Secretary William Hague also declined to comment on intelligence matters.

In Tripoli, Anes Sherif, an aide to Belhaj, said the documents provided little new information: "We have known for a long time that (the British and U.S. governments) had very close relations with Gadhafi's regime."

Amid the shared intelligence and names of terror suspects are traces of personal relationships.

In one letter from Dec. 24, 2003, a British official thanks Gadhafi's spy chief Moussa Koussa ? who later became foreign minister and defected early in the uprising ? for a "very large quantity of dates and oranges" and encourages him to continue with reforms.

"Your achievement realizing the Leader's initiative has been enormous and of huge importance," the British official says. "At this time sacred to peace, I offer you my admiration and every congratulation.

Source: http://us.rd.yahoo.com/dailynews/rss/world/*http%3A//news.yahoo.com/s/ap/20110903/ap_on_re_mi_ea/ml_libya_cia

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Saturday, September 3, 2011

Turkey says it will challenge Gaza blockade (AP)

ANKARA, Turkey ? Turkey is preparing to challenge Israel's blockade on Gaza at the International Court of Justice, the foreign minister said Saturday, racheting up tensions between the once close allies.

Ahmet Davutoglu's comments came a day after Turkey expelled the Israel's ambassador and severed military ties with the country angered over its refusal to apologize for last year's deadly raid on a Gaza-bound aid flotilla that killed nine pro-Palestinian activists.

In an interview with Turkey's state-run TRT television, Davutoglu dismissed a U.N. report into the raid that said Israel's naval blockade of Gaza was a legal security measure. Davutoglu said the report ? prepared by former New Zealand Prime Minister Geoffrey Palmer, and former Colombian President Alvaro Uribe, and presented to U.N. Secretary General Ban Ki-moon ? was not endorsed by the United Nations and was therefore not binding.

"What is binding is the International Court of Justice," Davutoglu said. "This is what we are saying: let the International Court of Justice decide."

"We are starting the necessary legal procedures this coming week," he said.

The minister said the U.N. report released Friday contradicted an earlier report on the Gaza flotilla incident which found that Israeli forces violated international law when they raided the flotilla. That report was prepared in September by three human rights experts appointed by the U.N.'s top human rights body.

Davutoglu also warned Israel that it risks alienation among Arab nations by resisting an apology.

"If Israel persists with its current position, the Arab spring will give rise to a strong Israel opposition as well as the debate on the authoritarian regimes," he said.

On Friday, Turkey downgraded diplomatic ties to the level of second secretary and gave the ambassador and other high-level diplomats until Wednesday to leave the country. In other measures against Israel, Turkey suspended military agreements, promised to back legal actions against Israel by the raid victims' families and vowed to take steps to ensure freedom to navigate in the eastern Mediterranean.

Turkish officials refused to elaborate on the last move, but some analysts suggested Turkey could send navy vessels to escort aid ships in the future while Turkey's main opposition party on Friday warned such a step could lead to confrontation between Turkish and Israeli forces.

"The probability that (Prime Minister Recep Tayyip Erdogan's ruling) party has carried Turkey to the brink of a hot conflict is saddening and unacceptable," said Faruk Logoglu, a deputy chairman of the opposition Republican People's Party.

Earlier on Saturday, Ban urged Turkey and Israel to mend ties for the good of the Middle East peace process.

"I sincerely hope that Israel and Turkey will improve their relationship," Ban told reporters during a visit to Australia.

"Both countries are very important countries in the region and their improved relationship ? normal relationship ? will be very important in addressing all the situations in the Middle East, including the Middle East peace process," he said, referring to a negotiated Palestinian-Israeli peace pact.

In Jerusalem, Prime Minister Benjamin Netanyahu's spokesman said the U.N. committee's report concluded that Israel had acted within its rights and said he hoped it would help "put the relationship between Jerusalem and Ankara back on the right track."

"The U.N. commission clearly states that Israel acted legally in imposing the naval blockade to protect our people from the smuggling of rockets and weapons that are fired at our civilians," the spokesman, Mark Regev, said.

The U.N. report released Friday called the May 31, 2010 Israeli raid "excessive and unreasonable." The U.N. panel also blamed Turkey and flotilla organizers for contributing to the deaths.

Israel insists its forces acted in self-defense and says there will be no apology. Israeli officials pointed out that the report does not demand an apology. Rather, it says "an appropriate statement of regret should be made by Israel in respect of the incident in light of its consequences."

Source: http://us.rd.yahoo.com/dailynews/rss/mideast/*http%3A//news.yahoo.com/s/ap/20110903/ap_on_re_eu/un_israel_turkey

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Friday, September 2, 2011

Gibson deal with ex-girlfriend heads to court

(AP) ? A judge is scheduled to discuss financial details of a settlement between Mel Gibson and his ex-girlfriend in a long-running custody dispute over their young daughter.

Both the Oscar winner and Russian musician Oksana Grigorieva are expected to appear in a Los Angeles courtroom Wednesday, when final issues of their agreement will be handled.

Court officials say Superior Court Judge Peter Lichtman will handle financial issues in open court, but details about the former couple's custody arrangements will be closed to the public.

The actor-director and his ex-girlfriend have been fighting for more than a year, and her allegations of domestic abuse prompted a criminal case against Gibson. He pleaded no contest to domestic battery earlier this year without acknowledging any wrongdoing.

Their daughter turns 2 in November.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-08-31-People-Mel%20Gibson/id-18182ef455b84ee4a061018e9fd07c1e

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AP Exclusive: Japan nuke holdout resolved to stay

In this photo taken Friday, Aug. 19, 2011, Naoto Matsumura's dog Aki runs to meet him while he checks on his rice paddy in Tomioka town, Fukushima, northeastern Japan. Nearly six months after Japan's catastrophic earthquake and tsunami, the 53-year-old believes he is the only inhabitant left in this town sandwiched between the doomed Fukushima Dai-ichi nuclear power station to the north and another sprawling nuclear plant to the south. (AP Photo/Hiro Komae)

In this photo taken Friday, Aug. 19, 2011, Naoto Matsumura's dog Aki runs to meet him while he checks on his rice paddy in Tomioka town, Fukushima, northeastern Japan. Nearly six months after Japan's catastrophic earthquake and tsunami, the 53-year-old believes he is the only inhabitant left in this town sandwiched between the doomed Fukushima Dai-ichi nuclear power station to the north and another sprawling nuclear plant to the south. (AP Photo/Hiro Komae)

In this photo taken Friday, Aug. 19, 2011, Naoto Matsumura and his dog Aki return home after he checks on his rice paddy in Tomioka town, Fukushima, northeastern Japan. Nearly six months after Japan's catastrophic earthquake and tsunami, the 53-year-old believes he is the only inhabitant left in this town sandwiched between the doomed Fukushima Dai-ichi nuclear power station to the north and another sprawling nuclear plant to the south. (AP Photo/Hiro Komae)

In this photo taken Friday, Aug. 19, 2011, ivy grows over a street in Tomioka town, Fukushima, northeastern Japan. Vines creep across Tomioka's empty streets, its prim gardens overgrown with waist-high weeds and meadow flowers. Dead cows rot where they were left to starve in their pens. Chicken coops writhe with maggots, a sickening stench hanging in the air in this nuclear no-man's land poisoned by radiation from a disaster-battered power plant. (AP Photo/Hiro Komae)

In this photo taken Friday, Aug. 19, 2011, Naoto Matsumura calls on cows in Tomioka town, Fukushima, northeastern Japan. Later Matsumura, who routinely drives around the town to feed wondering animals, said he forgot to bring food for them. Nearly six months after Japan's catastrophic earthquake and tsunami, the 53-year-old believes he is the only inhabitant left in this town sandwiched between the doomed Fukushima Dai-ichi nuclear power station to the north and another sprawling nuclear plant to the south. (AP Photo/Hiro Komae)

TOMIOKA, Japan (AP) ? Vines creep across Tomioka's empty streets, its prim gardens overgrown with waist-high weeds and meadow flowers. Dead cows rot where they were left to starve in their pens. Chicken coops writhe with maggots, a sickening stench hanging in the air.

This once-thriving community of 16,000 people now has a population of one.

In this nuclear no-man's land poisoned by radiation from a disaster-battered power plant, rice farmer Naoto Matsumura refuses to leave despite government orders. He says he has thought about the possibility of getting cancer but prefers to stay ? with a skinny dog named Aki his constant companion.

Nearly six months after Japan's catastrophic earthquake and tsunami, the 53-year-old believes he is the only inhabitant left in this town sandwiched between the doomed Fukushima Dai-ichi nuclear power station to the north and another sprawling nuclear plant to the south.

"If I give up and leave, it's all over," he told The Associated Press. "It's my responsibility to stay. And it is my right to be here."

Matsumura is an anomaly in a country where defiance of the government is rare and social consensus counts above everything else. Yet, Matsumura's quiet civil disobedience speaks loudly of the dilemma facing the more than 100,000 silent "nuclear refugees" who were displaced by the March 11 disaster.

Tokyo was quick to establish evacuation zones around the plant but has been slow to settle the refugees. A government order forbids them from going back to their homes in a half dozen towns around Fukushima Dai-ichi that were declared off-limits after the tsunami-stricken nuclear plant started spewing radioactivity.

"We are already being forgotten," said Matsumura, a leathery but clean-cut man with the sturdy build of a farmer. "The rest of the country has moved on. They don't want to think about us."

Tomioka's city hall has been moved to a safer city in Fukushima prefecture, where thousands of its residents live in makeshift shelters. Thousands more have scattered across the country.

The town itself is sealed behind police barriers, which hide the heart of the nuclear no-go zone, an area that is officially too dangerous for human habitation.

Officers are sent into Tomioka each day to search for burglars or violators of the keep-out order. By law, anyone caught inside the zone can be detained and fined.

But authorities mostly turn a blind eye to Matsumura, though he says he has been confronted by the police a few times. If there are other holdouts, they have escaped detection.

"Some people stayed behind, some stayed with me in my house," he said. "But the last one left a few weeks ago. He asked me to take care of his cats."

Tomioka official Tomio Midorikawa, who is in charge of the town's living and environment division, said the last resident was persuaded to leave in early August ? the same time Matsumura claims his neighbor left. He was not aware of Matsumura.

Without electricity or running water, Matsumura fires up a pair of old generators each night and draws his water from a local well. He eats mostly canned foods, or fish that he catches himself in a nearby river. He said that once or twice a month, he makes his way to a city outside the zone in his mini pickup truck to stock up on supplies and gas.

He has taken it upon himself to tend to the town's abandoned cats and dogs, including the wolflike Aki.

"I've gone to Tokyo a couple of times to tell the politicians why I'm here," he said. "I tell them that it was an outrage how the cows were left to die, and how important it is for someone to tend to the family graves. They don't seem to hear me. They just tell me I shouldn't be here to begin with."

Matsumura said he did leave once, but the ensuing experience only strengthened his desire to return.

"I drove to a relative's house thinking I would stay there," he said. "But she wouldn't let me in the door, she was too afraid I was contaminated. Then I went to an evacuation center, but it was full. That was enough to convince me to come home."

The tsunami disaster left nearly 21,000 people dead or missing and touched off fires, explosions and meltdowns at the Fukushima nuclear plant. The amount of radioactive cesium released into the environment since has been estimated to be equal to 168 Hiroshimas, making it the worst atomic disaster since Chernobyl.

No one ? including Matsumura ? is suggesting the exclusion zone be lifted altogether. The connection between radiation and cancer or other health problems is well established, and experts agree it could be decades until the nuclear zone is safe. Some point to the example of Chernobyl, which 25 years later is still mostly void of human life.

"The contaminants will be there for decades, centuries, millennia," said Timothy Mousseau, a biologist with the University of South Carolina who has studied Chernobyl for more than a decade and recently returned from a preliminary research trip to Fukushima.

Even so, local authorities are increasingly frustrated with the lack of progress toward resolving the nuclear Diaspora.

Tamotsu Baba, the mayor of Namie, a partially evacuated town near Tomioka, said in an interview it was reasonable at first for Tokyo to establish a geometric ring extending outward from the center of the plant. But he believes data collected since should be used to fine-tune the exclusion area to reflect the actual amounts of contamination.

"We have invested millions in developing a system to measure radiation," he said. "But it is like the whole thing is being decided by someone behind a desk with a 500 yen ($5) compass."

Further fanning the anger among the displaced, compensation from the government and Tokyo Electric Power Co., the utility that runs the plant, has stalled in a bureaucratic labyrinth.

Before the crisis began, the average annual income in Tomioka was about 3.5 million yen ($35,000).

Matsumura said he has received about 1 million yen ($10,000) in compensation, far less than he would have earned from selling his rice and other produce. TEPCO, reeling financially from the accident, has put off a final decision on further compensation until the plant is stabilized. The money already handed out will be subtracted from the amount it eventually settles on.

Officials say some restrictions may be lifted by the end of the year if the Fukushima reactors are brought to a stable shutdown.

Beyond that, the future remains a mystery.

"There are many tasks ahead before we will be able to return to our town, including decontamination and the rebuilding of our sewage system, roads and infrastructure," Tomioka Mayor Katsuya Endo said in a recent post on the town's website. "But we must maintain our hope, and gradually move forward."

Matsumura now likens himself to the Japanese soldiers who refused to surrender until decades after the end of World War II.

As a heavy rain began to fall, he walked down an overgrown mountain path to his rice paddy. He pulled up a plant by its roots, twisted it between his fingers then tossed it into an irrigation ditch with a resigned sigh.

There will be no cash crop this year. Or maybe ever again.

"It was strange being alone at first, but I am resolved to stay," he said. "I'm getting used to this life."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-08-31-AS-Japan-Earthquake-The-Holdout/id-def21d82c84644a19353da95586cd0df

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Thursday, September 1, 2011

Offers a Certificate in Entrepreneurship | World news and information


Posted: Tuesday, 30 August 2011 10:00 | Update: 21:45, Mon 29th August 2011

students should look at all the major at Purdue, AOS and Certificate programs and other business opportunities Burton D. Morgan Center for Entrepreneurship.

Last May I did Trek Discovery Park every morning at 8 o?clock in the morning (usually at random in the middle of spring shower) to finish the first leg of my travel certificate business. Despite the early hour, and Mother Nature, not the agenda of the AOS, I discovered a passion for business, which is useful for when I finish. The business environment is a capitalist success of the U.S. economy. From the media, medicine, commerce and ultimately result in some of the money. The acquisition of knowledge in business development and business insight can be the difference between debt and future financial stability of a bankruptcy proceeding. We have all the latest Purdue achieve. Regardless of class or occupation of choice, you will be part of the business after graduation. When perusing a lot of new graduates and potential employers continue to see a candidate with experience in business and realize the benefits of hiring a person. Universities understand this aspect of the employer, the AOS thinking and offer opportunities for students to get this experience. Ball State and Indiana University to offer business majors and minors in their business schools, but many students are aware that the educational experience at Purdue offers more flexibility

Purdue conducted under the Certificate in Entrepreneurship and Innovation is a way to gain experience in all major business and to improve their CV, while focusing on their core training. By creating a certificate program, not to big or small, Purdue allows each student to participate at any time.

Students must take two compulsory courses and three optional courses in the certificate, or a cornerstone. To make the program more flexible and free of any large list of options and Capstone courses include a variety of college, many of which overlap with other medical details of the AO. Although the completion of the program, students team to create business ventures and learn how to successfully pursue its business. Student teams in the business classes to continue their projects after the course, often after a really successful product or company. Burton D. Morgan also owns Center sponsors a variety of business competitions throughout the year. Burton D. 25 years Morgan Business Plan Competition will take place in February this year, during which the undergraduate and graduate students compete for $ 100,000 cash prizes

Any student interested in entrepreneurship, or Purdue, AOS certificate program can stop by the Burton D. Morgan Center, located in Discovery Park, or visit purdue.edu / discoverypark / ent.

Kinsey Streib is a Junior College of Liberal Arts and can be reached at opinions@purdueexponent.org pubDate Posted on Tuesday, August 30, 2011 10 : 00 Updated: 21:45

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Source: http://worldnews365online.com/business/entrepreneurship/2011/08/30/offers-a-certificate-in-entrepreneurship.html

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