Wednesday, October 31, 2012

Who can fix political gridlock? Poll favors Romney

Republican presidential candidate, former Massachusetts Gov. Mitt Romney shakes hands with supporters during a campaign stop at the University of Miami, Wednesday, Oct. 31, 2012, in Coral Gables, Fla. (AP Photo/Lynne Sladky)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney shakes hands with supporters during a campaign stop at the University of Miami, Wednesday, Oct. 31, 2012, in Coral Gables, Fla. (AP Photo/Lynne Sladky)

FILE - In this Sept. 13, 2011 file photo shows the Joint Select Committee on Deficit Reduction, led by co-chairs Rep. Jeb Hensarling, R-Texas, and Sen. Patty Murray, D-Wash., meeting on Capitol Hill in Washington to hear testimony about the national debt from the Congressional budget director. Just about everybody agrees Washington is a mess. But who can fix it? After two years of strife and stalemate between Obama and congressional Republicans, more voters trust Romney than Obama to break through the gridlock, an Associated Press-GfK poll shows. Romney's message _ a vote for Obama is a vote for more impasse _ seems to be getting through. Supercommittee members from left are Rep. Fred Upton, R-Mich., Rep. Xavier Becerra, D-Calif., Hensarling, Murray, Senate Minority Whip Jon Kyl of Ariz., Senate Finance Committee Chairman Sen. Max Baucus, D-Mont., Sen. Rob Portman, R-Ohio, Sen. John Kerry, D-Mass., and Sen. Pat Toomey, R-Pa. (AP Photo/J. Scott Applewhite, file)

FILE - This Oct. 26, 2011 file photo shows Supercommittee members, from left, Sen. Jon Kyl, R-Ariz., Sen. Max Baucus, D-Mont., Sen. Rob Portman, R-Ohio, and Sen. John Kerry, D-Mass., take part in a hearing on Capitol Hill in Washington. Just about everybody agrees Washington is a mess. But who can fix it? After two years of strife and stalemate between Obama and congressional Republicans, more voters trust Romney than Obama to break through the gridlock, an Associated Press-GfK poll shows. Romney's message _ a vote for Obama is a vote for more impasse _ seems to be getting through (AP Photo/J. Scott Applewhite, File)

President Barack Obama and New Jersey Gov. Chris Christie visit the Brigantine Beach Community Center to meet with local residents, Wednesday, Oct. 31, 2012, in Brigantine, NJ. Obama traveled to Atlantic Coast to see first-hand the relief efforts after Superstorm Sandy damage the Atlantic Coast. (AP Photo/Pablo Martinez Monsivais)

(AP) ? Just about everybody agrees Washington is a gridlocked mess. But who's the man to fix it? After two years of brawling and brinkmanship between President Barack Obama and congressional Republicans, more voters trust Mitt Romney to break the stalemate, an Associated Press-GfK poll shows.

Romney's message ? a vote for Obama is a vote for more gridlock ? seems to be getting through. Almost half of likely voters, 47 percent, think the Republican challenger would be better at ending the logjam, compared with 37 percent for Obama.

With the race charging into its final week, Romney is pushing that idea. He increasingly portrays himself as a get-things-done, work-with-everybody pragmatist, in hopes of convincing independent voters that he can overcome Washington's bitter partisanship. The AP-GfK poll shows the race in a virtual dead heat, with Romney at 47 percent to Obama's 45 percent, a difference within the margin of sampling error.

At a rally Wednesday in Coral Gables, Fla., Romney recounted how he worked with the Democratic-led Legislature as governor of Massachusetts and insisted he would find common ground with Democrats in Washington, too: "We can't change course in America if we keep attacking each other. We've got to come together and get America on track again."

Obama made his own show of bipartisanship Wednesday, touring superstorm Sandy devastation alongside Republican Gov. Chris Christie in New Jersey. A major Romney supporter, Christie has been praising Obama's "outstanding" response to the natural disaster.

Obama counters the Washington gridlock question by predicting that Republican lawmakers focused on opposing his re-election will become more cooperative once he wins a second term and becomes ineligible to run again. Referring to the top Republicans in Congress, Obama joked he would "wash John Boehner's car" or "walk Mitch McConnell's dog" to help get a federal deficit-cutting deal.

Obama also argues that Romney is more conservative these days than when he was elected governor and will find his newer ideas don't go down easily with Senate Democrats. For example, Romney, who worked with legislators to pass a health care overhaul in Massachusetts, has vowed to repeal the Democrats' similar national health care law.

In the AP-GfK poll, about 1 out of 6 likely voters didn't take a side on the gridlock issue: 6 percent weren't sure who would do a better job at getting Washington moving and 10 percent didn't trust either man to break the impasse among congressional partisans.

"They all need to be taken by the ear by a grandma," voter Margaret Delaney, 65, said in frustration.

She lives in Janesville, Wis., the hometown of Republican vice presidential nominee Paul Ryan, and she's leaning toward voting for the GOP ticket. But when it comes to ending gridlock, Delaney thinks it may not matter whether Romney or Obama is president.

"I'm not sure either of them can do it," she said.

A political standoff last year came close to forcing the government to default on its bills and led Standard & Poor's to downgrade the United States' credit rating. Over the past two years, a Congress split between Republican and Democratic leadership posted one of the least productive sessions in history.

When lawmakers return after Election Day for a lame-duck session, they need to work together with Obama to solve some festering troubles, including the "fiscal cliff" ? a looming combination of higher taxes and spending cuts that could trigger another recession if Congress doesn't find a resolution.

If re-elected, Obama will almost certainly face another two years or more of divided government. Polling in the states suggests Republicans are likely to keep the control of the U.S. House that they won in 2010. And tea partyers who stymied efforts to reach a deficit-reduction deal seem certain to remain a substantial presence.

There's a good chance that a President Romney would face a split Congress, as well. Democrats appear to have an edge in holding onto their Senate majority, especially if the presidential race remains close. At least a dozen of the 33 Senate races remain competitive, making the overall outcome tough to predict.

Obama also likes to remind Democrats and like-minded independent voters that he serves as a check on congressional Republicans. The president suggests Romney would be unwilling to stand up to "the more extreme parts of his party."

Leigh Westholm of Pensacola, Fla., said that's why she supports Obama's re-election even though she doesn't think he will be able to make peace with House Republicans.

"It takes two to tango and he has tried and tried for four years," Westholm said. "It might be better for Romney, but I don't agree with his views."

But Romney supporter Gary Bivins, a 57-year-old West Chester, Ohio, retiree volunteering in his first presidential campaign, says don't blame Congress.

A president needs the ability to lead, he said, and "I think Obama has shown no skill in that area."

The Associated Press-GfK Poll was conducted Oct. 19-23 by GfK Roper Public Affairs and Corporate Communications. It involved landline and cellphone interviews with 1,186 adults nationwide, including 839 likely voters. Results for the full sample have a margin of sampling error of plus or minus 3.5 percentage points, for likely voters it is 4.2 points.

___

AP News Survey Specialist Dennis Junius and AP writers Todd Richmond in Wisconsin, Melissa Nelson-Gabriel in Pensacola, Dan Sewell in Cincinnati and Kasie Hunt in Florida contributed to this report. The questions and results are available at http://www.ap-gfkpoll.com .

___

Follow Connie Cass on Twitter: http://www.Twitter.com/ConnieCass

Follow Jennifer Agiesta on Twitter: http://www.Twitter.com/JennAgiesta

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2012-10-31-Campaign-Gridlock%20Nation/id-081ef74443c44519bb1f9a4114b4f1c9

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Thursday, October 11, 2012

Man behind anti-Muslims film denies violating probation

Mona Shafer Edwards / AP

This Sept. 27 courtroom sketch shows Mark Basseley Youssef, right, talking with his attorney Steven Seiden in court. Youssef was behind an anti-Muslim film that sparked violence in the Middle East.

By NBC News staff and wire services

Updated at 5:44 p.m. ET: LOS ANGELES --?A California man who was behind an anti-Muslim film that sparked violent protests in the Middle East denied on Wednesday he violated his probation stemming from a 2010 bank fraud conviction.?

U.S. District Judge Christina Snyder ruled that?Mark Basseley Youssef will remain in custody and?scheduled an evidentiary hearing for Nov. 9.?

Youssef, 55, has been in a federal detention center since Sept. 28 after he was arrested for eight probation violations and deemed a flight risk by another judge. Prosecutors said Youssef lied to his probation officers about his real name and used aliases.?


Youssef answered "deny" eight times when the judge asked him to respond to the allegations, which include lying to the probation officer about his role in the making of the controversial 13-minute "Innocence of Muslims" movie clip.

Youssef fled his home in the Los Angeles suburb of Cerritos and went into hiding when violence erupted in Egypt on Sept. 11 over the trailer of "Innocence of Muslims" that was posted on YouTube. The trailer depicts Mohammad as a religious fraud, womanizer and pedophile.

The unrest spread, killing dozens, and enraged Muslims have demanded severe punishment for Youssef, with a Pakistani cabinet minister offering $100,000 to anyone who kills him.?The violence coincided with a separate attack on U.S. diplomatic facilities in Benghazi that killed four Americans, including the U.S. ambassador to Libya.

Watch the most-viewed videos on NBCNews.com

Youssef's attorney, Steven Seiden, asked the court during Wednesday's brief hearing that his client be taken out of protective custody at the federal prison and released into the general population. Snyder ordered the prosecutor to meet with personnel at the federal Bureau of Prisons to determine whether that can be done, Southern California Public Radio reported.

"My client was not the cause of the violence in the Middle East," Seiden said after Wednesday's hearing. "Clearly, it was pre-planned and it was just an excuse and a trigger point to have more violence." ??

A judge will decide whether or not Nakoula Basseley Nakoula, the producer behind the 'Innocence of Muslims' film, violated the terms of his 2010 conviction on bank fraud charges. NBC's Savannah Guthrie reports.

Youssef, a Christian originally from Egypt, was convicted of bank fraud in 2010 and sentenced to 21 months in prison. After he was freed, he was barred from using computers or the Internet for five years without approval from his probation officer. He also wasn't supposed to use any name other than his true legal name without the prior written approval of his probation officer. ??

"It will be interesting to see what the judge does and what the reaction is around the world,'' Stan Goldman, a Loyola Law School professor, told Reuters. ? ?

Goldman said attorneys for Youssef could argue the terms of his 2011 release from prison did not apply directly to his recent activities, in which people associated with the film have said he misrepresented himself. ?

"It's not exactly like an armed robber on probation, getting caught with an automatic weapon in his possession. It's a little more technical,'' Goldman said.

At least three names have been associated with Youssef since the film trailer surfaced -- Sam Bacile, Nakoula Basseley Nakoula and Youssef. ??

Court documents show Youssef legally changed his name from Nakoula in 2002, but he never told federal authorities while he was being prosecuted for check fraud. Orange County Superior Court documents show he wanted the change because he believed Nakoula sounded like a girl's name.? ?

Youssef sought a passport in his new name but still had a California driver's license as Nakoula, authorities said.? ?

Authorities said Youssef used more than a dozen aliases and opened about 60 bank accounts and had more than 600 credit and debit cards to conduct the check fraud scheme.? ?

Bacile was the name attached to the YouTube account that posted the video.

The probation issues were the latest of Youssef's legal woes. Cindy Lee Garcia, an actress who says she was duped into appearing in the anti-Islam film, has sued him, identifying him as the film's producer. Garcia also named YouTube and its parent company Google as defendants.? ?

Google has refused to remove the film from YouTube, despite pressure from the White House and others, though the company has blocked the trailer in Egypt, Libya and other Muslim countries.

The Associated Press and Reuters contributed to this report.

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Source: http://usnews.nbcnews.com/_news/2012/10/10/14347548-man-behind-innocence-of-muslims-film-denies-violating-probation?lite

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Wednesday, October 10, 2012

Striking Out Prostate Cancer | Visual.ly


Visual.ly empowers people to tell stories with data.


Mich. man at risk for meningitis after losing wife

This undated family photo provided by George Cary shows Lilian Cary of Howell, Mich. Friends and family gathered Monday, Oct. 8, 2012, for a wake for 67-year-old Cary who died in September, weeks after being treated with contaminated steroids for back pain. Officials say the number of Michigan fungal meningitis cases is climbing. The number now stands at 22, including a non-meningitis infection of a joint. Two women have died. (AP Photo/Family Photo, George Cary)

This undated family photo provided by George Cary shows Lilian Cary of Howell, Mich. Friends and family gathered Monday, Oct. 8, 2012, for a wake for 67-year-old Cary who died in September, weeks after being treated with contaminated steroids for back pain. Officials say the number of Michigan fungal meningitis cases is climbing. The number now stands at 22, including a non-meningitis infection of a joint. Two women have died. (AP Photo/Family Photo, George Cary)

DETROIT (AP) ? Days after taking his wife off life support, George Cary got a phone call that confirmed his suspicions: Her meningitis-related death was linked to tainted steroid injections at a Michigan clinic that had regularly treated her back pain.

The doctor on the call had more tough news. Cary's own back injections in September may have come from a contaminated batch too.

Cary went to an emergency room last weekend for a spinal tap. The test results aren't in yet, so he is left to wait and say goodbye to his wife, 67-year-old Lilian Cary, at a memorial service Tuesday.

"They advised me to watch for symptoms," Cary, 65, told The Associated Press from a funeral home in Howell, 60 miles northwest of Detroit. "At this point, there's nothing abnormal, but they said the same thing when Lilian had hers. ... Not only have I lost my wife, but I'm watching the clock to see if anything develops."

Michigan has at least 21 cases of meningitis related to steroid shots made by a specialty pharmacy in Massachusetts. Those cases include the deaths of Lilian Cary and a 56-year-old woman whose identity and hometown haven't been released by public health officials.

Meningitis is an inflammation of the lining of the brain and spinal cord, and a back injection would put any contaminant in more direct contact with that lining. Separately, a Michigan resident developed a nonmeningitis fungal infection after being injected in a joint, not the back, the state Department of Community Health reported.

Lilian Cary died Sept. 30. She had been ill since late August, but meningitis wasn't detected until Sept. 22, her husband said.

Nonetheless, her health seemed to be improving at University of Michigan hospital.

"She was responding to medication. Her spirits were up. Her fever was broken," George Cary said. "She was walking the hallway and Skyping with grandsons."

But she became unresponsive Sept. 26, and eventually was removed from life support after suffering a stroke, he said.

Cary said he was informed Saturday that his wife had been treated with tainted steroids for back pain. The doctor at Michigan Pain Specialists in Brighton, one of four Michigan clinics to get shipments from the Massachusetts pharmacy, said Cary also was at risk.

"The whole staff is devastated," said Cary, who declined to disclose the doctor's name. "The people there are professionals. I have the greatest respect for their care. They truly care about the people they treat. They're suffering just as much as I am."

No one could be reached for comment Monday at Michigan Pain Specialists. The phone number was repeatedly busy.

Lilian Cary was a native of Stoke-on-Trent, England, who immigrated to the U.S. in 1965 to work as a nanny. The Carys met in Mount Kisco, N.Y., and were married in 1977. They moved to Michigan in 2000 after many years in the St. Louis area and have lived in Howell since 2003.

Lilian Cary liked to play bunco, a dice game, and belonged to a club that welcomed transplants like herself to Livingston County.

"I've lost my best friend," George Cary said.

___

Follow Ed White on Twitter at http://www.twitter.com/edwhiteap

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2012-10-09-Meningitis%20Outbreak-Michigan/id-6d22f24fed9e4648be8584ecc24aee99

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Huge ammunition explosion rocks Russian city

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Monday, October 8, 2012

Jennifer Aniston Engagement Ring: Not Small!

Source: http://www.thehollywoodgossip.com/2012/10/jennifer-aniston-engagement-ring-not-small/

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Japan pension fund considers investing in alternative assets

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Tuesday, October 2, 2012

Adult stem cells change their epigenome to generate new organs

Adult stem cells change their epigenome to generate new organs [ Back to EurekAlert! ] Public release date: 2-Oct-2012
[ | E-mail | Share Share ]

Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute

A study developed by IDIBELL researchers, led by Manel Esteller, has identified epigenetic changes that occur in adult stem cells to generate different tissues of the human body

The team led by Manel Esteller, director of the Cancer Epigenetics and Biology Program in the Bellvitge Biomedical Research Institute (IDIBELL), Professor of Genetics at the University of Barcelona and ICREA researcher, has identified epigenetic changes that occur in adult stem cells to generate different body tissues. The finding is published this week in The American Journal of Pathology.

The genome of every single cell in the human body is the same, regardless of their appearance and function. Therefore the activity of the tissues and organs and its disorders in complex diseases, such as cancer, cannot be fully explained by the genome. It is necessary something more, and part of the explanation is provided by epigenetics, which is defined as "the inheritance of DNA activity that does not depend on strict sequence of it." That is, if genetics is the alphabet, spelling would be the epigenetics, which refers to chemical changes in our genetic material and their regulatory proteins. The most known epigenetic mark is the addition of a methyl group to DNA. Thus, the epigenome is getting all the epigenetic marks of a living being.

Adult stem cells have an enormous potential to regenerate damaged organs and their use also avoids ethical complications involving embryonic stem cells, as well as technical problems arising from induced stem cells. In this study, researchers have isolated stem cells from body fat and transformed them into muscle and bone cells. Then, it was necessary to know how much resembled are the cells created in the laboratory with those present in one individual and if they were biologically secured enough to be implanted in patients. The study shows that the epigenome of the cells obtained in culture closely resembles that of skeletal muscle cells and they are spontaneously present in nature, although not completely identical.

A key point of the study is that muscle and bone cells produced in the laboratory do not have the tumour epigenome derived from these tumour tissues (rhabdomyosarcoma and osteosarcoma, respectively) so they are safe from a biological perspective. The study coordinator, Manel Esteller, stresses that the research "demonstrates the usefulness of epigenetics in determining the degree of maturity and biosecurity of differentiated tissues used in regenerative medicine against different diseases."

###

Article reference

DNA Methylation Plasticity of Human Adipose-Derived Stem Cells in Lineage Commitment. Berdasco M, Melguizo C, Prados J, Gomez A, Alaminos M, Pujana MA, Setien F, Ortiz R, Zafra I, Aranega A, Esteller M. The American Journal of Pathology, published online 01 October 2012.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Adult stem cells change their epigenome to generate new organs [ Back to EurekAlert! ] Public release date: 2-Oct-2012
[ | E-mail | Share Share ]

Contact: Ral Toran
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute

A study developed by IDIBELL researchers, led by Manel Esteller, has identified epigenetic changes that occur in adult stem cells to generate different tissues of the human body

The team led by Manel Esteller, director of the Cancer Epigenetics and Biology Program in the Bellvitge Biomedical Research Institute (IDIBELL), Professor of Genetics at the University of Barcelona and ICREA researcher, has identified epigenetic changes that occur in adult stem cells to generate different body tissues. The finding is published this week in The American Journal of Pathology.

The genome of every single cell in the human body is the same, regardless of their appearance and function. Therefore the activity of the tissues and organs and its disorders in complex diseases, such as cancer, cannot be fully explained by the genome. It is necessary something more, and part of the explanation is provided by epigenetics, which is defined as "the inheritance of DNA activity that does not depend on strict sequence of it." That is, if genetics is the alphabet, spelling would be the epigenetics, which refers to chemical changes in our genetic material and their regulatory proteins. The most known epigenetic mark is the addition of a methyl group to DNA. Thus, the epigenome is getting all the epigenetic marks of a living being.

Adult stem cells have an enormous potential to regenerate damaged organs and their use also avoids ethical complications involving embryonic stem cells, as well as technical problems arising from induced stem cells. In this study, researchers have isolated stem cells from body fat and transformed them into muscle and bone cells. Then, it was necessary to know how much resembled are the cells created in the laboratory with those present in one individual and if they were biologically secured enough to be implanted in patients. The study shows that the epigenome of the cells obtained in culture closely resembles that of skeletal muscle cells and they are spontaneously present in nature, although not completely identical.

A key point of the study is that muscle and bone cells produced in the laboratory do not have the tumour epigenome derived from these tumour tissues (rhabdomyosarcoma and osteosarcoma, respectively) so they are safe from a biological perspective. The study coordinator, Manel Esteller, stresses that the research "demonstrates the usefulness of epigenetics in determining the degree of maturity and biosecurity of differentiated tissues used in regenerative medicine against different diseases."

###

Article reference

DNA Methylation Plasticity of Human Adipose-Derived Stem Cells in Lineage Commitment. Berdasco M, Melguizo C, Prados J, Gomez A, Alaminos M, Pujana MA, Setien F, Ortiz R, Zafra I, Aranega A, Esteller M. The American Journal of Pathology, published online 01 October 2012.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-10/ibri-asc100212.php

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Housing Recovery? It's Going to be a While | Daily Business News

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> Economy, News Item, Trends > Housing Recovery? It?s Going to be a While



RealtorMag says home prices may not return to their peak of 2007 for ten years, especially in Nevada, California, Florida, and Arizona, according to analytics firm Fiserv. Noting average prices fell a full one third from 2007 to 2012 across the nation, Fiserv predicts prices will rise 3.7 percent a year for the next five years, but that will still leave them 20 percent below peak. In some areas like West Virginia, Texas, and South Dakota prices have already edged higher. As MHProNews has learned, due to the devastating flooding of the Souris River last year and the oil boom which have combined to create a housing shortage, North Dakota has seen prices rise 17.7 percent in the last five years.

(Image credit: HousingWire)

Categories: Economy, News Item, Trends Tags: Fiserv, housing shortage, MHProNews, nevada california, next five years, North Dakota, oil boom, Souris River, South Dakota, West Virginia

Source: http://www.mhmarketingsalesmanagement.com/blogs/daily-business-news/housing-recovery-its-going-to-be-a-while/

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Monday, October 1, 2012

Pauken responds to Hammond (Offthekuff)

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Russian church urges Pussy Riot members to repent

MOSCOW (AP) ? The Russian Orthodox Church is asking for clemency for three jailed members of the rock band Pussy Riot if they repent for their "punk prayer" for deliverance from President Vladimir Putin at Moscow's main cathedral.

Sunday's church statement comes a day before the women's first appeal since they were convicted on hooliganism charges and sentenced to two years last month.

The church said that if the women make statements showing "penitence and reconsideration of their action," they "shouldn't be left unnoticed."

Earlier this month, Russian Prime Minister Dmitry Medvedev said that keeping them in prison any longer would be "unproductive" ? a statement that encouraged hopes the appeals court could set them free. But skeptics pointed at the Kremlin's ongoing crackdown on dissent, saying that their release would be unlikely.

Source: http://news.yahoo.com/russian-church-urges-pussy-riot-members-repent-104540471.html

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Scientists find missing link between players in the epigenetic code

ScienceDaily (Sep. 30, 2012) ? Over the last two decades, scientists have come to understand that the genetic code held within DNA represents only part of the blueprint of life. The rest comes from specific patterns of chemical tags that overlay the DNA structure, determining how tightly the DNA is packaged and how accessible certain genes are to be switched on or off.

As researchers have uncovered more and more of these "epigenetic" tags, they have begun to wonder how they are all connected. Now, research from the University of North Carolina School of Medicine has established the first link between the two most fundamental epigenetic tags -- histone modification and DNA methylation -- in humans.

The study, which was published Sept. 30, 2012 by the journal Nature Structural & Molecular Biology, implicates a protein called UHRF1 in the maintenance of these epigenetic tags. Because the protein has been found to be defective in cancer, the finding could help scientists understand not only how microscopic chemical changes can ultimately affect the epigenetic landscape but also give clues to the underlying causes of disease and cancer.

"There's always been the suspicion that regions marked by DNA methylation might be connected to other epigenetic tags like histone modifications, and that has even been shown to be true in model organisms like fungus and plants," said senior study author Brian Strahl, PhD, associate professor of biochemistry and biophysics in the UNC School of Medicine and a member of UNC Lineberger Comprehensive Cancer Center. "But no one has been able to make that leap in human cells. It's been controversial in terms of whether or not there's really a connection. We have shown there is."

Strahl, along with his postdoctoral fellow Scott Rothbart, honed in on this discovery by using a highly sophisticated technique developed in his lab known as next generation peptide arrays. First the Strahl lab generated specific types of histone modifications and dotted them on tiny glass slides called "arrays." They then used these "arrays" to see how histone modifications affected the docking of different proteins. One protein -- UHRF1 -- stood out because it bound a specific histone modification (lysine 9 methylation on histone H3) in cases where others could not.

Strahl and his colleagues focused the rest of their experiments on understanding the role of UHRF1 binding to this histone modification. They found that while other proteins that dock on this epigenetic tag are ejected during a specific phase of the cell cycle, mitosis, UHRF1 sticks around. Importantly, the protein's association with histones throughout the cell cycle appears to be critical to maintaining another epigenetic tag called DNA methylation. The result was surprising because researchers had previously believed that the maintenance of DNA methylation occurred exclusively during a single step of the cell cycle called DNA replication.

"This role of UHRF1 outside of DNA replication is certainly unexpected, but I think it is just another way of making sure we don't lose information about our epigenetic landscape," said Strahl.

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The above story is reprinted from materials provided by University of North Carolina Health Care, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Scott B Rothbart, Krzysztof Krajewski, Nataliya Nady, Wolfram Tempel, Sheng Xue, Aimee I Badeaux, Dalia Barsyte-Lovejoy, Jorge Y Martinez, Mark T Bedford, Stephen M Fuchs, Cheryl H Arrowsmith, Brian D Strahl. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nature Structural & Molecular Biology, 2012; DOI: 10.1038/nsmb.2391

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/7_XQCq_v1FA/120930142111.htm

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Turkey, Egypt slam Syrian regime

ANKARA, Turkey (AP) ? Turkey and Egypt sought to boost their alliance in a turbulent region on Sunday, unleashing harsh criticism of the Syrian regime and pledging joint support for the Palestinian cause.

Egypt's new president, Mohammed Morsi, addressed a major congress of Turkish Prime Minister Recep Tayyip Erdogan's ruling party, amid signs that a partnership between their two countries is emerging, and said they both plan to stand by Palestinians and the Syrian people.

"Our common goal is to support other people who are standing up against their administrations or regimes, to support Palestine and the Syrians in their efforts," Mursi said.

"The events in Syria are the tragedy of the century," Morsi said. "We will be on the side of the Syrian people until the bloodshed ends, the cruel regime is gone and Syrian people reach their just rights."

In his speech to the congress, which is marking the ruling Justice and Development party's decade in power, Erdogan promised that Turkey, which is host to some 88,000 Syrian refuges as well as Syrian opposition groups, would continue to support the Syrian people wanting to oust the regime of President Bashar Assad.

He appealed to Russia, China and Iran to stop backing the regime.

"We call on Russia, China as well as Iran: please review your stance. History will not forgive those who stand together with cruel regimes," he said.

With Khaled Mashaal, the leader of the Palestinian Islamic militant group Hamas also present, Erdogan said Turkey is determined to speak out against what he called Israel's "state terrorism" in the region and praised Morsi for his support to Palestinians.

"Through Morsi's leadership, our Palestinian brothers in Gaza and in all other Palestinian cities are able to breathe easily," he said.

Erdogan said Turkey would not reconcile with former ally Israel until it lifts its blockade of Gaza and apologizes for an attack in 2010 that killed nine mostly Turkish pro-Palestinian activists in a raid on a flotilla that tried to breach the blockade.

Israel has refused to apologize but has expressed regret for the loss of lives. It insists troops opened fire after coming under attack by activists.

During his 12-hour visit to Turkey, Morsi will try to strengthen economic ties with Turkey ? a country his Muslim Brotherhood group views as an Islamic success story, mixing a strong economy with Western ties and Islamic piety.

Turkish Foreign Minister Ahmet Davutoglu visited Cairo earlier this month and pledged a $2 billion in aid to boost confidence in an economy badly battered by a tourism slump, strikes and ongoing protests since the fall of the authoritarian leader Hosni Mubarak in an uprising last year.

Earlier, Erdogan told delegates at the congress that the era of military coups in the country is over and that Turkey is a model for other Muslim countries to emulate.

The Justice and Development Party, which came to power in 2002, has maintained Turkey's decades-old secular system, but at the same time has curtailed the power of the military, which have staged three coups since the 1960s and forced an Islamic government out of office in 1997.

Earlier this month, a court sentenced more than 300 military officers to long prison terms for attempting to topple the government in 2003.

"The era of coups in this country will never return again," Erdogan said. "Anyone who intervenes or tries to intervene in democracy will sooner or later go in front of the people's courts and be made to account."

Source: http://news.yahoo.com/turkey-egypt-slam-syrian-regime-143112221.html

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Comings & Goings - WestportNow.com - Westport, Connecticut's 24 ...

Sunday, September 30, 2012

Comings & Goings: The Groove to PRW

WestportNow.com Image
The Groove, a children?s apparel and gift store, will open around Oct.15 at 420 Post Road West, across from Whole Foods, according to Westport co-owners Corri Neckritz (l) and Erin Berk.? Berk describes the store as ?a hip destination with a boutique-y feel.?? Neckritz said in addition to kids apparel, ?we?ll have overnight bags, fun jewelry, purses, toys and other things.? The 1,284-square foot space was formerly occupied by Coppola Marble and Granite. Groove can be reached at .(JavaScript must be enabled to view this email address) and at (203)557-8111. (CLICK TO ENLARGE) Dave Matlow for WestportNow.com

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Note: WestportNow Publisher Gordon F. Joseloff is also First Selectman of Westport

Source: http://www.westportnow.com/index.php?/v2/40211/

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